Singleton-Merten syndrome (SMS) is an autosomal dominant, multi-system innate immune disorder characterized by early and severe aortic and valvular calcification, dental and skeletal abnormalities, psoriasis, glaucoma, and other varying clinical findings.Recently we identified a specific gain-of-function mutation in IFIH1, interferon induced Belts
The past decade has seen numerous efforts to enact cannabis policy reform at the state level.This visualization captures discursive shifts in statewide ballot initiatives devoted to legalizing cannabis for recreational use Belts between 2012 and 2022.The topics discussed in ballot initiatives exhibited substantial variability over time, with discus
OBJECTIVES: The aim of this study was to analyze the immunolabeling of two cell cycle protein regulators, p53 and p21WAF1, in non-dysplastic leukoplakias with different epithelial alterations: acanthosis, hyperkeratosis and acanthosis combined with hyperkeratosis, and compare them with dysplastic leukoplakias.MATERIAL AND METHODS: This was a prospe
Cellular senescence is a complicated process featured by irreversible cell cycle arrest and senescence-associated secreted phenotype (SASP), resulting in accumulation of senescent cells, and low-grade inflammation.Cellular senescence not only occurs during the natural aging of normal cells, but also can be accelerated by various pathological factor